SYNTHETIC OSTEOBIOLOGICS

1. 100% fusion rate in 1, 2 and 3 level anterior standalone cervical interbody fusion
2. High success in lumbar and sacroiliac joint fusions

NanoFuse Biologics LLC, wholly owned by NANISX LLC (a KIC Ventures portfolio company), is an FDA-cleared synthetic bioactive ceramic 45S5 bioglass osteobiologics unique formulation for bone regeneration, promoting fusion and healing. When combined with aqueous body fluid, NanoFuse forms a 3D ultra-porous calcium hydroxyapatite layer within 24 hours, creating a strong bond with adjacent bone. This process triggers osteoblast differentiation, accelerates osteogenesis, and enhances bone growth. Additionally, in vitro studies show ionic release (Ca) and pH changes inherent to bioactive glass create an unfavorable environment for microbes, adding an antimicrobial benefit.

Guided by LESS™ REP principles - Restore Function, Early Intervention, and Preserve Anatomy, NanoFuse Biologics is a trusted bone void filler for fusion and regeneration. With a proven clinical record and patented manufacturing, NanoFuse Biologics LLC delivers a reliable bone regeneration solution.

"The results suggest that new bone induction by DBM was accelerated by the presence of bioactive glass implants. "

Ann Chir Gynaecol Suppl. 1993:207:137-43. Induction of new bone by allogeneic demineralized bone matrix combined to bioactive glass composite in the rat. K J Pajamäki 1, O H Andersson, T S Lindholm, K H Karlsson, A Yli-Urpo

Our Manufacturing

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Synthetic Osteobiologics

FDA-Cleared 2015

Indications For Use

NanoFuse® Bioactive Matrix is indicated to be gently placed into bony voids or gaps of the skeletal system that are not intrinsic to the stability of the bony structure (i.e., the extremities, pelvis and posterolateral spine). These defects may be surgically created osseous defects or osseous defects created from traumatic injury to the bone. NanoFuse® Bioactive Matrix must be used with autograft as a bone graft extender.