NanoFuse Research
Featured Study
Kingsley R Chin 1, Chukwunonso C Ilogu, Sukanya Chebrolu, William M Costigan, Erik Spayde, Vito Lore, Douglas P Beall, Robby Lane, Josue P Gabriel, Aditya Humad, Jason A Seale.
This in vitro study compared the osteoinductive potential of recombinant BMP-2, bioactive glass (BAG), demineralized bone matrix (DBM), and a composite nano-BAG + DBM formulation (NanoFuse DBM) using a C2C12 alkaline phosphatase assay. Results demonstrated that wet/frozen DBM produced the highest alkaline phosphatase activity, while NanoFuse DBM at higher concentration exceeded the assay’s detection limit and outperformed BMP-2, DBM + gel, and BAG-based formulations. BMP-2 showed comparatively lower osteogenic activity at the tested dose, and BAG alone exhibited minimal induction. Overall, the findings suggest that NanoFuse DBM provides robust, dose-dependent osteoinductive activity and may represent a safer and more effective alternative to BMP-2 and traditional graft materials for spinal fusion and other orthopedic applications, warranting further in vivo investigation.
NanoFuse Biologics Bioglass Studies
01
Int J Spine Surg . 2025 Dec 28;19(6)
Kingsley R Chin 1, Chukwunonso C Ilogu, Sukanya Chebrolu, William M Costigan, Erik Spayde, Vito Lore, Douglas P Beall, Robby Lane, Josue P Gabriel, Aditya Humad, Jason A Seale
02
Cell Tissue Bank. 2013 Mar;14(1)
Osteoconductivity and osteoinductivity of NanoFUSE(®) DBM
James F Kirk 1, Gregg Ritter, Chad Waters, Sonoko Narisawa, José Luis Millán, James D Talton
03
International Journal of Biomedical Materials Research. 2015 July;3(3)
James F. Kirk, Gregg Ritter, Michael J. Larson, Robert C. Waters, Isaac finger, John Waters, John H. Abernethy, Dhyana Sankar, James D. Talton, Ronald R. Cobb
04
Acta Biomater. 2011 Jun;7(6)
Bioactive glass in tissue engineering
Mohamed N Rahaman 1, Delbert E Day, B Sonny Bal, Qiang Fu, Steven B Jung, Lynda F Bonewald, Antoni P Tomsia
05
Nanomaterials (Basel). 2024 Jul 13;14(14):1196.
Current and Future Perspectives of Bioactive Glasses as Injectable Material
Andreea-Luiza Mîrț, Denisa Ficai, Ovidiu-Cristian Oprea, Gabriel Vasilievici, Anton Ficai
06
Cureus. 2021 Jul 15;13(7)
Kingsley R Chin , Fabio J Pencle, Jason A Seale, Deepak K Pandey
45S5 Bioglass Antibacterial Studies
01
Pathogens. 2025 Aug 1;14(8):760. doi: 10.3390/pathogens14080760.
Humera Sarwar, Richard A Martin, Heather M Coleman, Aaron Courtenay, Deborah Lowry
02
Mater Sci Eng C Mater Biol Appl. 2021 Dec:131:112453. doi: 10.1016/j.msec.2021.112453. Epub 2021 Sep 25.
B R Spirandeli 1, R G Ribas 2, S S Amaral 3, E F Martins 1, E Esposito 1, L M R Vasconcellos 3, T M B Campos 2, G P Thim 2, E S Trichês 4
03
BMC Microbiol. 2022 Sep 2;22(1):212. doi: 10.1186/s12866-022-02617-8.
Comparison of antibacterial and antibiofilm activity of bioactive glass compounds S53P4 and 45S5
Peng Zhou 1 2, Brittny L Garcia 2, Georgios A Kotsakis 3 4
Pending Publication
01
Efficacy of an FDA Approved Synthetic Nano-Bioactive Glass Plus Demineralized Bone Matrix (DBM) Combination versus DBM Alone in Instrumented Lumbar Fusion for Low-Grade Degenerative Spondylolisthesis: A Prospective Randomized Controlled Trial Pilot Study
02
A Prospective Randomized Controlled Trial Comparing Nano-Bioactive Glass plus Demineralized Bone Matrix (DBM) vs. DBM Alone in Single-Level ACDF with Standalone PEEK Cages
03
An In Vitro Study of Alkaline Phosphatase Induction as a Quantitative Measure of the Osteoinductive Potential of FDA-Approved Nano-Bioactive Glass Combined with Demineralized Bone Matrix (DBM) vs Bioactive Glass Alone and DBM Alone